As an alternative [to IM Ceftriaxone or oral cefixime] against gonorrhea, which two drugs are effective in a single oral dose? Quinolones As an alternative [to IM Ceftriaxone or oral cefixime] against gonorrhea, which two drugs are effective in a single oral dose? (You don't give them together, you can use either of them alone) Answer: Ofloxacin OR Ciprofloxacin Learn More : Share this Share on FacebookTweet on TwitterPlus on Google+